In the early 70s. Marianne Seifert (Charlotte Schwab) fears for the lives of her sons. You’re a hemophiliac, any minor injury can be fatal. A bicycle accident of the youngest, Ralf (Max Riemelt, Max Boekhoff) seems to be a stroke of luck: Marianne learns of a new type of treatment. With the help of the medication the brothers Ralf, Thomas (David Rott) and Stefan (Fabian Busch, Thilo Berndt) can lead a normal life. The medical miracle has a name: Factor VIII is a coagulant obtained from blood donations that makes hemophiliacs seemingly carefree. However, like many other patients, they are infected with AIDS due to HIV-contaminated blood. When the brothers learn that they are HIV positive, they begin to fight against the constant fear of the outbreak of the disease and its discovery, which led to total social exclusion in the 1980s. In the family there is a quarrel and the early death of one of the three brothers is an additional burden. But above all Ralf does not want to subordinate his life completely to the illness. Supported by the young doctor Martina Meissner, he struggles to prove the path of transmission and to hold those responsible for the disaster to account.