In San Francisco, video game creator Thomas A. Anderson lives his life, but can’t shake the suspicion that something is wrong. Slowly he begins to doubt his own sanity, something even the pills he swallows every day can’t change. A woman he meets looks familiar, though he can’t place her. And seemingly complete strangers (Jessica Henwick and Yahya Abdul-Mateen II) approach him and claim to know him as „Neo.“ Could it be that his world is just an illusion he needs to escape – and not for the first time?